Activation of coagulation factor VII during alimentary lipemia.

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Activation of coagulation factor VII during alimentary lipemia.

Dietary studies have established a connection between plasma lipoproteins and coagulation factor VII. The present study was undertaken to specifically examine whether factor VII is activated during alimentary lipemia and to investigate the relations of factor VII mass and activity state with fasting and postprandial lipoproteins and free fatty acids (FFAs). Factor VII levels were therefore dete...

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Acquired deficiency of coagulation factor VII

Factor VII (FVII) is found in small amounts in plasma and has a very short half-life in circulation. FVII is vitamin K-dependently synthesized in the liver. As such, hepatopathies, vitamin K deficiency, or use of vitamin K antagonists is the cause of acquired deficiency. Other types of acquired FVII deficiencies are rare.1 Here we describe a case of acquired factor VII deficiency associated to ...

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Alimentary Lipemia and the Coagulability of Blood

THE effect of alimentary lipemia on coagulation has been a matter of controversy for most of the past decade. Reports have confirmed and denied an acceleration of whole blood coagulation.'-'0 A considerable amount of evidence is growing that purports to show lipemia as a factor in the pathogenesis of thrombotic disease, and perhaps even a factor in the genesis of atheroselerosis.1' These specul...

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Effect of protamine on alimentary lipemia.

The effect of protamine on the serum lipids during alimentary lipemia was investigated in normal male students and this effect was compared with that in atherosclerotic and in nonatherosclerotic men of the same age group. In the student group protamine produced a highly significant increase in the total fatty acid level, whereas in the 2 older groups no significant change occurred. These result...

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Activation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency.

Factor VII activity (FVIIc), a risk marker for coronary heart disease, is increased during postprandial lipemia. Factor VII activation accompanies lipolysis of triglyceride-rich lipoproteins, but the nature of this association and whether it is causal remain uncertain. To explore this issue, four patients with homozygous factor XII deficiency, four with complete factor XI deficiency, six with f...

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ژورنال

عنوان ژورنال: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology

سال: 1994

ISSN: 1049-8834

DOI: 10.1161/01.atv.14.1.60